I've been thinking about this quite a bit as well. It seems like the most likely way that any kind of revolutionary movement would come to fruition in the US, as a countrywide revolution seems many levels more difficult.
Seeing CHAZ in Seattle during the BLM protests planted the seed in my head, specifically in the case of a Cascadia-type state. It would be a difficult split though to be sure, the USA would have a lot to lose to a breakaway state and I'm sure would put up a fight against it. If US imperialism is weakened enough and spread thin in conflicts elsewhere in the world, it could be a moment of opportunity for such a movement if proper organization is in place.
I also wonder if as US empire declines, and turns inward, if capitalist infighting will lead to some level of balkanization anyway.