I've only done it a few times, but nitrous made me laugh so much, it was great. Nitrous starts fading as soon as you breathe out and is over in 10min tops, but for weed, give yourself an evening to get stoned for the first time. Feeling cramped for time is a huge vibe killer.

Also, modern weed can be way too strong for a first-timer, but if you can find a low-thc/high-cbd strain, you'll have smooth sailing. My poor in-laws hadn't smoked since the 60s, and the budtender sold them a thc vape, good times were not had. Don't make their mistake, haha.