use something like distrobox, bottles, flatpak to run extra software
YES! That's my plan! I think I just figured out how to configure flakpak a little better.
These are only part of the steps needed: https://flatpak.org/setup/GNU%20Guix
You also need to source ~/.guix-profile/etc/profile.d/flatpak.sh in order to get the desktop icons to show up in the GNOME app launcher. (Using guix home for that!)
Need to work on getting distrobox setup next. I was able to guix install distrobox, but it requires some extra configuration apparently.