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Smallpox is the only infectious disease to be successfully iradicated. The last case occured in 1978. However, the US (CDC) and Russia maintain samples of the virus for research purposes, despite the WHO's recommendation that all samples of the virus be destroyed.
Given the current state of things, I wouldn't consider it completely impossible for some very stable genius to accidently -- or maybe not accidentally -- release the virus back into the wild.
When people are sending their pox, they're not sending their best pox. They're sending small pox, chicken pox. Can you believe that? Chick pox! And now the price is eggs so high because of all the chickens with the pox.