Yep, I can for example rebase from Bazzite to Secureblue and keep all of my configs intact for say, KDE. So if a project goes fubar you aren't out of luck and need to reinstall and reconfig linux, its trivial to rebase/"swap distro", its a single command that looks like this

rpm-ostree rebase ostree-image-signed:docker://ghcr.io/ublue-os/bazzite-dx-nvidia:stable

All programs, files, configs, etc are intact in your home directory. I've swapped between user created spins for different DEs like Cosmic and so on, whats cool is its all preconfigured to run well under bazzites kernel. Image based upgrades are also very nice, theres inevitably config drift that messes with performance or updates can break your setup on other distros, image based means the devs tweak every interaction and push it all to you with the least effort possible on your part.