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I agree. There's far too many variables even if OP is a reliable narrator.
Why their metabolism of caffeine (half life is only 5 hours normally) is so slow is what I'd look into first with a doctor. A tiny fraction of people metabolize caffeine extremely slowly due to genetic variations in the CYP1A2 enzyme apparently. Another reason is...liver disease.
Also, just coffee "radically" altering their blood pressure. Huh? Elaborate OP.
Sure. What else do you want to know?