I assume you mean Nginx Proxy Manager? I'm surprised that you would even run that on a desktop with a GUI, seems far more fit for a headless system. Of course, nothing stops you - it's your system.

As a general note I'd recommend docker CLI / compose, most applications will assume you're using that and have instructions tailored for it (which is helpful if you're new to docker).

To be honest I didn't even know docker had a desktop app for Linux, I've only seen folks use it on Windows and macOS.