It would definitely be milder and slower.
Safe? Nothing is.

If you want to fuck with your brain, then doesn't matter whether you choose poppy seeds or IV its refined chemical. You will still fuck your brain.
And coffee is pretty much an addiction.

The difference is that with the former, you would at least know what is happening to you before you turn yourself into an invalid.
And for those who said they didn't know what was happening... No. Your body gave you the signs and you decided to ignore them.

Allopathic drugs are measured in mg and some even in µg, while you will see ayurvedic stuff being talked about in grams or tens of grams, simply because they are less refined.