If you mean using different models, yes. If you mean finetuning model weights... No, finetuning LLMs is hard in general and Strix Halo (device that I had in mind that costs 3K$ for 128GB of VRAM) is also kinda bad for it now due to having an AMD (and not really strong when it comes to compute power) GPU.
In practice, people who try finetuning on top of newest models usually cripple them. There are plenty of finetunes of Qwen 3.6 on huggingface trying to distill stronger models and they are just bad.
Heretic, the method for removing refusals I mentioned, also requires more VRAM to run it than it's required for inference.