The Senate made more sense when the US was less centralized and different states were like different countries and there weren't a bunch of states populated by 100 cows for every person.

In the modern era, it's a simple tyranny of the minority. Wyoming has like 500,000 people, but those 500,000 have the exact same power in the more important chamber of Congress than do the 40,000,000 of California or the 30,000,000 of Texas.

If we take it to an extreme, imagine if there were only two states in the Union. Hawaii and the entire Continental US. Would we share equal power with Hawaii? Of course not.

If we're really married to the idea, there should be a requirement for roughly equal population by state, and let's be honest, we have that with House districts and they gerrymander it. (We should also move to proportional representation to fix that.)