"eat any good books lately?"

"do not confuse composure with ease" is one I quote a lot. It's not easy being broken but I learned to be composed about it so nobody can see it

“You know, I'm really easy to get along with - most of the time - but I don't like bullies, and I don't like threats - and I don't like you”

Edit: A close second is “Survival is insufficient”

“I hate temporal mechanics”

And

“He was more than a hero. He was a union man!”

If we're just talking voyager, it's "Delete the wife". If we're talking all of trek, it might be "Hey Worf, Eat any good books lately?"

Tom : "What do you think? Boy or a girl?"

Seven : "It's a holographic projection."

Probably the grocery store line, but I'm a chatty fellow.

"Computer, deactivate iguana."

"I know"

"Gentlemen, I suggest you beam me aboard."

-TOS: The Doomsday Machine

Runner-up quote: "This is highly improbable."

-TNG: Cause and Effect