My wife runs a large online D&D guild, with games 4-5 nights a week (not that you play in all of them, they just have that many people). They're no strangers to kicking people that cause drama, and they have several trans and non-binary members already.
I will say that they might not be able to bring their character in, as-is, if it's heavily based on "official" D&D lore and sourcebooks. The group has spent 8 years building all their own lore and tuning some homebrew rules and classes. It's mostly built on the 5e foundation, though.
I believe this is where they'd go to apply.