jet

I hate April's fools

why not make a community for your political discussions?

Make a new account, transfer the community to the new account, in your original account leave the mod team, in the new account purge the account

This will remove the communities from your account, and not leave them with a fake moderator, they will be clearly abandoned

Use a VPN like zerotier or tailscale to connect to your game host server.

This will punch through your firewall and it won't expose your server to the raw internet

yeah, 100%. Not everybody gets gout, there is clearly a genetic profile that can develop gout... in the current metabolic context, and the modern diet.

People can't control their genetics, they can control their metabolism, and their diet.

Fructose has uric acid as a byproduct of its metabolism [86]. Fructose induced hyperuricemia has a pathogenetic role in metabolic syndrome [78,87]. Higher insulin concentrations, associated with metabolic syndrome, reduce the renal excretion of uric acid [47,80,88]. Uric acid is an inhibitor of nitric oxide synthase, [78] which is the catalyst for nitric oxide, critical for circulatory and immune homeostasis.

Reducing circulating uric acid concentrations is one of the mechanistic components of improved blood pressure control that is observed with a reduction in fructose intake [89].

• Except from https://doi.org/10.1016/C2019-0-03604-7 section 7.3 Pathophysiology of gout

Here are the references

• 47 - https://doi.org/10.1016/j.semnephrol.2011.08.004
• 78 - https://doi.org/10.3899/jrheum.170806
• 80 - https://doi.org/10.1186/1758-5996-4-12
• 86 - https://doi.org/10.1152/physrev.00019.2009
• 87 - https://doi.org/10.1152/ajprenal.00140.2005
• 88 - https://doi.org/10.1001/jama.1991.03470210076036
• 89 - https://doi.org/10.1093/ajh/hpaa044

All of that is to say elevated uric acid is not the root of the problem, its a symptom of the core problem.

Quotes from the paper https://doi.org/10.1038/s41588-024-01921-5

Over recent decades, the incidence of gout has steadily increased, largely due to lifestyle factors such as diet, obesity, and metabolic conditions

The paper also indicates a global rise in gout going hand in hand with the rise in global metabolic dysfunction.

Having looked at the paper, it good, really good... but the genetic factors are for a population in the current metabolic context (high carb diets, poor metabolic health). Some people can tolerate the modern food landscape really well, and those people don't get gout (hence this paper). But just because people's genetics are intolerant of the current food landscape, doesn't mean they HAVE to get gout.... It can be avoided, by cutting out carbs, fructose, and alcohol. So even if you have a genetic sensitivity that leads to gout, you can simply not eat the foods necessary for the condition.

Here is the full paper: https://www.medrxiv.org/content/10.1101/2025.02.07.25321834v1.full.pdf

That's true, but the root cause of gout is carbs and fructose and alcohol. Lowering uric acid when gout is acute makes sense, but long term you want to get off the sugars and alcohols.

The CICO model isn't helpful to most people.

I strongly think we need to stop telling people about CICO. It's a thermodynamic model, not a clinical model.

It's much better to use the insulin obesity model, it's a clinical model - https://hackertalks.com/post/7617450

Basically we are not Bomb Calorimeters. You can eat uranium with billions of calories and not gain weight. We are hormonal machines, which have amazing homeostasis feedback already built it, we have to eat appropriately so those systems actually work.

An illustrative example: if you want to lose 1lbs in a month you have to eat 30 calories less per meal. Nobody is going to measure their calories that accurately, not to mention food labels can be 25% off the exact amount.. which means every meal you are eating +-208 calories.. (on a 2500kcal day diet).

I'd say most of the active conversations on Lemmy are in the stress you out category.

Did she single handedly tank the performance of the film? No

Did her activities outside of the film help the film get good pr and positive buzz? Also no

National security letters and research... That's why there is zero information, it's all sealed.

That's why the lawyer won't say anything, they are not allowed to.

Wasn't unheard of for PhD students at my university to get their research made secret while their PhD was in progress...created huge headaches for everyone, especially if they couldn't get clearance to even see/finish their research.