Nanoplastics in particular can wind up in the bloodstream and throughout the body. At the nanoscale, the immune system will recognize plastic particles as pathogens and then macrophages will envelop and attempt to digest them. That causes all sorts of inflammatory signals to be put out. That then accelerates inflammaging and all of the associated diseases and conditions. There's clear evidence for every step of this, the remaining hurdle is quantifying just how much damage it's doing.
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