This one got me puzzled, so I googled it and the best I could find is

Some are as simple as claiming that the man in the comic is blind, explaining why the newspaper is blank and that he possibly mistook a bowl of meat for a bowl of fruit. Other theories are as deep as thinking that the comic is meant to symbolize the mistreatment and deterioration of the American middle class by the upper crust. Whichever theory is correct is still up in the air, but one thing is for certain is that no one truly knows what this strip is about.

From screenrant

The Res-erection of Christ

Leela: Space bandidos have been operating in this quadrant so you'll each take 8-hour shifts guarding the safe. First Bender, then Flexo, then Fry.

Fry: Wait, hold on. I don't like the sound of that. Let's just go alphabetically

Leela: OK. First Bender, then Flexo, then Fry.

Fry: Wait, let's go by rank.

Leela: OK. First Bender, then Flexo, then Fry.

Fry: Flexo outranks me?

Flexo: That's "Flexo outranks me, sir"!

You can tell they're laying groundwork for the remedy verse with Alan Wake 2, including Quantum Break

:::

With Tim Breaker (played by Shawn Ashmore, aka Jack Joyce) in the dark place, dreaming he's living whole other lives. Plus Mr Door/Mr Hatch

:::

Nothing says buy seal penises like... Taylor swift?

Is the simulation collapsing into a Swift-ularity? She's suddenly at the center of everything, including seal meat. Wtf

But my gas and eggs are so expensive now and I still have to pay my student loans, surely Biden is the worst president ever?