Because perspectives get misaligned and there's no continuation.

There's a whole desk with books that just disappears. The poster in the background can't decide what it wants to say. Nor can it decide on its size. The shelves in front of it can't decide what they contain or where they are positioned And the wall it's on can't decide how it's angled relative to the room.

The "NO AI" dude is taking a giant step forward with his left foot behind a garbage bin for some reason.

In the third panel the doctor is missing a ring-finger while his thumbs have grown 3-4cm

Just to name a few.

The "uncanny" part I think isn't because it's done badly, it's because it's done well - but not in any of the ways you'd get from a human. By the time a human artist has learned to get that good at shading, colouring, line work, human figures, posing etc, they'll have also learned about composition and perspective and good storytelling and when to not pointlessly overload the background with weird shit.